Formulation for anti-alpha4beta7 antibody

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专利权人:

Inc.;Millennium Pharmaceuticals

发明人:

Diluzio, Willow,Nguyen, Phuong M.,Varga, Csanad M.,Palaniappan, Vaithianathan,Brown, Jason,Fox, Irving H.,Scholz, Catherine,Jenkins, Helen,Rosario, Maria

申请号：

AU2012250872

公开号：

AU2012250872B2

申请日:

2012.05.02

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.

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