Willow Diluzio,Phuong M. Nguyen,Csanad M. Varga,Vaithianathan Palaniappan,Jason Brown,Irving H. Fox,Catherine Scholz,Erica Helen Jenkins,Maria Rosario
申请号:
US15983791
公开号:
US20180327497A1
申请日:
2018.05.18
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.