A use of peanut skin extract in the manufacture of a composition is provided, wherein the composition is used for increasing expression ofPTPRDgene. The composition thus is effective in preventing or treating diseases related toPTPRDgene.一種使用花生膜萃取物於製備一組合物之用途,其中該組合物係用於提升PTPRD基因表現,從而達到預防或治療與PTPRD基因相關之疾病的效果。