The present disclosure provides a use of an extract of Selaginella tamariscina for inducing expression of keratin gene, hyaluronan synthase gene and filaggrin gene, enhancing the mitochondrial activity of cells, enhancing the moisture-retaining capacity of the skin, and anti-aging.本發明提供一種卷柏的萃取物用於提升角蛋白基因、透明質酸合成酶基因及絲聚蛋白基因的表現量、提升細胞的粒線體活性、提升皮膚的保濕能力及抗老化之用途。