The present invention provides a use of Chimonanthus salicifolius extract for enhancing the gene expression of Chaperonin containing TCP1, PTEN-induced putative kinase 1, Parkinson juvenile disease protein, Autophagy-related gene, Sirtuin 1, Glutamine-dependent NAD+ synthetase, Mitochondrial ribosomal protein S5, and/or Ubiquitin-like protein. The Chimonanthus salicifolius extract can effectively delay skin and systemic aging, maintain mitochondrial activity and normal metabolism, and increase the concentration of NAD+ in cells, and has strong anti-glycation activity. The Chimonanthus salicifolius extract is prepared by extracting Chimonanthus salicifolius using water, alcohols, or mixtures of water and alcohols as solvents.本發明提供一種柳葉蠟梅萃取物用於提升含TCP1的折疊蛋白基因、PTEN促進激酶1基因、帕金森氏症少年蛋白基因、自噬作用相關基因基因、抗衰老酶1基因、麩醯胺酸依賴性菸草醯胺腺嘌呤二核苷酸合成酶基因、粒線體核糖體蛋白5基因、及/或泛素樣蛋白基因表現量的用途，該柳葉蠟梅萃取物能有效延緩皮膚及全身性的老化、維持粒線體活性及正常代謝、以及提升細胞中NAD+之濃度，且具有強效之抗醣化活性。其中該柳葉蠟梅萃取物係柳葉蠟梅以水、醇、或醇水混合物之溶劑所萃取而得。
