DONG WANG,OLIVIA D. HUI - WEBER,TODD K. JONES,CHERYL A. GRICE,JUSTIN S. CISAR
申请号：
ARP160100743
公开号：
AR104025A1
申请日:
2016.03.18
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
This document provides nitrates and pharmaceutical ingredients containing these compounds. The target compounds and compositions can be used as MAGL and / or abhd6 modulators. In addition, the compounds and compounds used also contribute to the treatment of pain. 1. Claim 1: a formula compound (1),Where R1 is halogen, or3,-Cn, arilo (alternative text is replaced by one, two or three parts selected from r830808 respectively)；a. Arilooxi (one, two or three scores selected from r830808 shall be used as alternatives)；a. Non-n-propene (optionally replaced by one, two or three parts selected from r830808 respectively)；a. Special ring west (one, two or three parts selected from r830808 shall be used for replacement)；a. Heterocycle (optionally replaced by one, two or three parts selected from r830808 respectively)；1. Cyclopropyl bromide (one, two or three parts selected from r830808 can be used as alternatives)；C₁₋₆ optionally substituted alkyl, C₂₋₆ optionally substituted alkenyl, C₂₋₆ optionally substituted alkynyl, NR⁹R¹⁰,No. 831222； C (o) r8313；-No. 831222； No. so8322238； No. 8313；-831222； (C (o) 8313；-831222； (C (o) 8313； (r183044)；-C (O) R-C (O) OR-C (o) No. 8313； r83044,-S (O) R o -SH R es -NR R-alkyl (NR¹⁴R¹⁵) or -OR⁷；each R³ is selected separately from H, C₁₋₆ alkyl, haloalkyl and aminoalkyl； each R⁴ is selected separately from halogen, -OR³,-CN, nitro, C₁₋₆ optionally substituted alkyl, C₁₋₆ optionally substituted alkenyl, C₁₋₆ optionally substituted alkynyl, cycloalkyl, -NR⁹R¹⁰,-831222； (C (o) r8313；-No. 831222； No. so8322238； No. 8313；-831222； (C (o) 8313；-831222； (C (o) 8313； (r183044, - C (o) r8313；-C (O) OR-C (o) No. 8313； r83044,-S (o) 695； R1 Y-sh； r83099 and r8310；In addition to nitrogen, they form (I) a single ring heterocycle, a fused double ring heterocycle or helix； or (II) a 7-8 member associative heterocycle, optionally containing an O, n or s； in which, a single ring heterocycle, The combined bicyclic cycle or Spirulina is replaced by one or more su
