GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
WAN, ZEHONG,REN, FENG,MA, XIN,HAO, XIN
申请号：
ARP180101214
公开号：
AR112187A1
申请日:
2018.05.09
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
An ingredient including a pharmaceutical ingredient: at least one pre pharmaceutical patent is acceptable. 2. Use the compound or the compound or its pharmaceutical components to make a drug for pain treatment. These compounds inhibit the activity of Nav1.7 and can be used to treat diseases transmitted through Nav1.7 activity. 1. A compound characterized by 2-oxo-benzo [D] oxazol-6-sulfur amide, characterized by formula (1) or an acceptable salt on a medicament of the compound,R1 is selected from a group consisting of (I) cyclopentadiene or C 83218331 asphalt；Including: lessor c8332131 832323,1. Replace with pyridine glycol or nh483222；(II) substituted phenyl with (ch8322s) - 8344739； r696；Where: m is 1 or 2, r739es h or methyl； r6966 is h, methyl, ch83222； ch8322；](III) methyl phenyl substitutes: methyl substituted with one to three substitutes independently selected from the group of Oh, halo, ch83222nh832222 and morpholinil； (IV) phenyl substitutes, substituted by isocyclopentyl of 4-6 members； Options: choose an alternative to isopropyl compounds in the methyl, halogen and methoxy groups； pentaphenyl, replaced by two independently selected alternatives, halogen and c8332183318333 tar；Among them: c83216c833183323 apartment can be replaced by a replacement person selected from n832222 apartment；N (CH 83223) 8322 and nhch832222 (C = O) nh8322；Hexaphenyl was replaced by tetrahydropyridine, where tetrahydropyridine was replaced by methyl, tetrahydropyridine by methyl, tetrahydropyridine by methyl, octahydrofluoropropylene, tetrahydrofluoroacrylonitrile by tetrahydropyridine； O halo and R3 are h or halo； wherein: one R2 and R3 is h, the other is halo； r83088 is methyl or h； het is heterosexual, with 5 to 6 members, consisting of 1 to 3 heterosexual atoms selected from n, s and O； and: heteromorphism can be replaced by halogens, c83218331 and alternatives selected from CN；Una composición farmacéutica que lo comprende: junto con al menos un excipiente farmacéuticamente
