Combinations of Brutons tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4- phenoxyphenyl)- 1 H-pyrazolo [3,4-d]pyrimidin- 1 -yl)piperidin- 1 -yl)prop-2-en- 1 -one, with CYP3A4 inhibitors are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Brutons tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1 H-pyrazolo [3, 4-d]pyrimidin-l - yl)piperidin-l-yl)prop-2-en-1-one, and CYP3A4 inhibitors.Se proporciona combinaciones de inhibidores de tirosina quinasa de Bruton (Btk), por ejemplo, 1-((R)-3-(4-amino-3-(4-fenoxifenil)- 1H-pirazolo [3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1-ona, con inhibidores de CYP3A4. Se proporciona, además, métodos para tratar cánceres y enfermedades autoinmunes al administrar combinaciones de inhibidores de tirosina quinasa de Bruton (Btk), por ejemplo, 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo [3,4]pirimidin-1-il)piperidin-1-il) prop-2-en-1-ona e inhibidores de CYP3A4.
