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Combinations of butons tyrosine kinase inhibitors and cyp3a4 inhibitors
- 专利权人:
- PHARMACYCLICS LLC
- 发明人:
- 申请号：
- IL24081815
- 公开号：
- IL240818D0
- 申请日:
- 2015.08.25
- 申请国别(地区):
- IL
- 年份:
- 2015
- 代理人:
- 摘要：
- The invention discloses combinations of Brutons tyrosine kinase inhibitors and CYP3A4 inhibitors. Combinations of Brutons tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4- phenoxyphenyl) - 1 H-pyrazolo [3,4-d] pyrimidin- 1 -yl)piperidin- 1 -yl)prop-2-en- 1 -one, with CYP3A4 inhibitors are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Brutons tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1 H-pyrazolo [3, 4-d] pyrimidin-l - yl) piperidin-l-yl) prop-2-en-1-one, and CYP3A4 inhibitors.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
