COMBINATIONS OF BRUTONS TYROSINE KINASE INHIBITORS AND CYP3A4 INHIBITORS

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专利权人:

发明人:

Maria FARDIS,Juthamas SUKBUNTHERNG

申请号：

US14774292

公开号：

US20160022683A1

申请日:

2014.03.12

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Combinations of Brutons tyrosine kinase (Btk) inhibitors, e.g., 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with CYP3A4 inhibitors are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of Brutons tyrosine kinase (Btk) inhibitors, e.g., 1-4((R)-3-(4-amino-3-(4-phenoxyphenyl)-1 H-pyrazolo[3, 4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, and CYP3A4 inhibitors.

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