Jonathan Lorne Bramson,Christopher W. Helsen,Joanne Alicia Hammill,Kenneth Anthony Mwawasi
申请号：
US16442274
公开号：
US10640562B2
申请日:
2019.06.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
