Jonathan Bramson,Christopher W. Helsen,Galina Denisova,Rajanish Giri,Kenneth Anthony Mwawasi
申请号：
US15117173
公开号：
US20160368964A1
申请日:
2015.02.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
