TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF

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专利权人:

McMaster University

发明人:

BRAMSON, Jonathan,HELSEN, Christopher W.,DENISOVA, Galina,GIRI, Rajanish,MWAWASI, Kenneth Anthony

申请号：

EP15746948

公开号：

EP3102681A4

申请日:

2015.02.06

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/