T cell-antigen coupler with Y182T mutation and methods and uses thereof

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专利权人:

McMaster University

发明人:

HELSEN, Christopher W.,BRAMSON, Jonathan,DVORKIN-GHEVA, Anna,DENISOVA, Galina F.,BEZVERBNAYA, Ksenia,MWAWASI, Kenneth Anthony

申请号：

AU2018349093

公开号：

AU2018349093A1

申请日:

2018.10.12

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/