PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACTION OF FLOWER APPLE AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
SAMYOUNG DISTRIBUTION AGRICULTURAL ASSOCIATION CORPORATION;삼영에프앤비 영농조합법인;안동대학교 산학협력단;삼영에프앤비 영농조합법인;안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
손호용,김동률,SOHN HO YONG,KIM DONG RYOUL
申请号：
KR1020180118269
公开号：
KR1020200038717A
申请日:
2018.10.04
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating thrombosis and a health functional food containing a flower apple ( Malus prunifolia Wild. Borkh) extract as an active ingredient, and more specifically, an extract of a flower apple mature fruit It relates to a pharmaceutical composition and a health functional food for preventing or treating / improving thrombosis through strong blood clotting inhibition and platelet aggregation inhibition using as an active ingredient. The pharmaceutical composition for the prevention or treatment of thrombosis of the present invention and the flower apple extract as an active ingredient of a health functional food exhibit strong antithrombotic activity through inhibition of platelet aggregation and inhibition of enzymes and blood clotting factors related to thrombus production, and at the same time, human Thrombosis such as ischemic stroke and hemorrhagic stroke through improvement of blood circulation because it does not show any hemolytic activity against red blood cells, has excellent thermal stability, and does not exhibit blood clotting and platelet aggregation inhibitory effects even in acidic conditions and plasma of pH 2. It is expected to be used as a pharmaceutical composition for prevention and treatment / improvement and health functional food, and the active ingredient is processed into various forms such as extract, powder, pill, tablet, etc. Effective, very useful inventors in the pharmaceutical and food industries A.본 발명은 꽃사과(Malus prunifolia Wild. Borkh) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 꽃사과 성숙과의 추출물을 유효성분으로 하는 강력한 혈액응고저해 및 혈소판응집저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 꽃사과 추출물은 혈전 생성 관련 효소 및 혈액 응고 인자의 저해와 혈소판 응집 저해를 통해 강력한 항혈전 활성을 나타냄과 동시에, 인간 적혈구에 대한 용혈 활성을 전혀 나타내지 않고, 열 안정성이 우수하고, pH 2의 산성 조건 및 혈장 내에서도 혈액응고저해 및 혈소판응집저해 효과의 손실이 나타나지 않으므로, 혈행 개선을 통해 허혈성 뇌졸중 및 출혈성 뇌
