PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF AN UNRIPE APPLE AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
손호용,심장섭,민철기,유용선,SOHN HO YONG,SHIM JANG SEOP,MIN CHEOL KI,YOO YONG SEON
申请号：
KR1020180096231
公开号：
KR1020757990000B1
申请日:
2018.08.17
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pharmaceutical composition for preventing or treating thrombosis and a health functional food containing an unripe apple extract as an active ingredient, and more particularly, a strong blood coagulation using the green apple extract as an active ingredient. The present invention relates to a pharmaceutical composition for the prevention or treatment / improvement of thrombosis through inhibitory activity and platelet aggregation inhibitory activity, and a dietary supplement. The green apple extract as an active ingredient of the preventive or therapeutic / improving thrombosis of the present invention and the health functional food exhibits strong antithrombotic activity through blood coagulation inhibitory activity and platelet aggregation inhibitory activity, and hemolysis to human erythrocytes. It exhibits no activity at all, has excellent thermal stability, shows no loss of blood coagulation inhibitory activity and platelet aggregation inhibitory activity even in acidic conditions and plasma of pH 2, thereby improving thrombosis such as ischemic stroke and hemorrhagic stroke through blood circulation improvement. It is expected that it can be used for therapeutic purposes. The active ingredient is processed in various forms such as extracts, powders, pills, tablets, etc., and thus it is very useful for the pharmaceutical industry and food industry because it has an excellent effect of preparing in a form that can be taken at all times. It is an invention.본 발명은 풋사과(unripe apple) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 풋사과 추출물을 유효성분으로 하는 강력한 혈액 응고 저해 활성 및 혈소판 응집 저해 활성을 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 풋사과 추출물은 혈액 응고 저해 활성 및 혈소판 응집 저해 활성을 통해 강력한 항혈전 활성을 나타냄과 동시에, 인간 적혈구에 대한 용혈 활성을 전혀 나타내지 않고, 열 안정성이 우수하고, pH 2의 산성 조건 및 혈장 내에서도 혈액 응고 저해 활성 및 혈소판 응집 저해 활성의 손실이 나타나지 않으므로, 혈행 개선을 통해 허혈성 뇌졸중 및 출혈성 뇌졸중과 같은 혈전증의 예방 및 치료용으로 사용
