CHRISTOPHER CHARLES FREDERICK HAMLETT,GILBERT EBAI BESONG,ANDREW JAMES WOODHEAD,GIANNI CHESSARI,STEVEN DOUGLAS HISCOCK,DAVID NORTON,SUSANNE MARIA SAALAU-BETHELL,NEIL THOMAS THOMPSON,HENDRIKA MARIA GER
申请号：
ARP120104076
公开号：
AR088596A1
申请日:
2012.10.31
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The compounds currently provided can be used to treat hepatitis C virus (HCV) infection. Claim 1: a compound characterized by formula (1),or a salt, N-oxide, tautomer or stereoisomer thereof, where: A is CH or nitrogen； E is CH or nitrogen； R¹ is selected from: a C₁₋₈ acyclic hydrocarbon group optionally substituted with one or two R⁶ substituents,where a carbon atom of the C₁₋₈ acyclic hydrocarbon group can optionally be replaced by a heteroatom or a group selected from O, S, NRᶜ,S (o) and so832222,O a group selected by conr758080 can be selected to replace the adjacent carbon atom c8321c83338328；NRᶜCO, NRᶜSO₂ and SO₂NRᶜ with the proviso that in each case there is at least one carbon atom of the acyclic hydrocarbon group C₁₋₈；And a single periodic or multi periodic carbon group composed of 3 to 7 ring members, in which 0, 1, 2, 3 or 4 are heteroatoms of ring members selected from O, N and s, in which one or two substitutes in r8311 can be selected to replace the carbon thyroid group or multi periodic group； 7491；R2 was selected from hydrogen and x-r831222 groups；X is a group of carbon atoms, in which one carbon atom can choose to combine with one unit - ch832222-ch8322；where n is between 1 and 5, to form a C₃₋₇-1,2-diyl cycloalkan group； R³ is a 3-10 membered monocyclic or bicyclic carbocyclic or heterocyclic ring containing 0, 1, 2 or 3 heteroatoms as ring members selected from N, O and S, and which is optionally substituted with one or more R¹³ substituents；R830808 from hydrogen and a r8308； 7491；R⁴ᵃ is selected from halogen； cyano； C₁₋₄-alkyl optionally substituted with one or more fluorine atoms； C₁₋₄ alkoxy optionally substituted with one or more fluorine atoms； hydroxy-C₁₋₄-alkyl；e. Alcoxi c83218d-833183228a - lease c83218c831248324；R83099a from hydrogen and r8309； 74919；R⁵ᵃ is selected from C₁₋₂ alkyl optionally substituted with one or more fluorine atoms； C₁₋₃ alkoxy optionally substituted with one or more fluorine atoms； halogen； cyclopropyl； and cyano； R⁶
