Jennifer Brogdon,Hilmar Erhard Ebersbach,David Glass,Thomas Huber,Julia Jascur,Carl H. June,Jihyun Lee,Joan Mannick,Michael C. Milone,Leon Murphy,Avery D. Posey,Huijuan Song,Yongqiang Wang,Lai Wei,Qil
申请号：
US15543688
公开号：
US20180118834A1
申请日:
2016.01.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated PGK promoter operably linked to a chimeric antigen receptor (CAR) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a tumor antigen as described herein.
