The Trustees of the University of Pennsylvania;Michael C. Milone;Yangbing Zhao;Daniel J. Powell, JR.;Novartis AG;Andreas Loew
发明人:
Andreas Loew,Michael C. Milone,Daniel J. Powell, Jr.,Yangbing Zhao
申请号：
US15126036
公开号：
US20170335281A1
申请日:
2015.03.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a cancer associated antigen as described herein.
