Stenmark, Pal Erik Gustav,Berntsson, Ronnie Per-Arne,Dong, Min,Peng, Lisheng
申请号：
AU2018200409
公开号：
AU2018200409A1
申请日:
2018.01.18
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018200409A120180301.pdf#####Abstract Botulinum neurotoxin (BoNT) polypeptides with a modified receptor binding domain of Clostridial botulinum serotype B (B-H,), comprising one or more substitution mutations corresponding to substitution mutations in serotype B, strain I, Vlll8M； Y1183M； E119IM； E11911； E119IQ； E119IT； S1199Y； S1199F； S1199L； SI 20 IV； or combinations thereof. Specific combination mutations include El 191M and SI 199L, El 191M and SI 199Y, El 191M and SI 199F, El 191Q and SI 199L, El 191Q and S 1 199Y, or E 1191 Q and S 1 199F. Other substitution mutations are also disclosed. Isolated modified receptor binding domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed.
