IADONATO, SHAWN P,MAGNESS, CHARLES L,ROSENBERG, GARY,SCHERER, CHRISTINA A,GUILLAUDEUX, THIERRY
申请号：
NZ59187904
公开号：
NZ591879A
申请日:
2004.10.22
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a polypeptide encoding a mutated oligoadenylate synthetase 1 (OAS 1). This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also disclosed is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided.
