MARQUESS, DANIEL,FATHEREE, PAUL R.,TURNER, S. DEREK,LONG, DANIEL D.,CHOI, SEOK-KI,GOLDBLUM, ADAM A.,GENOV, DANIEL
申请号：
CA2561558
公开号：
CA2561558C
申请日:
2005.04.06
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides quinolinone-carboxamide 5-HT4 receptor agonistcompounds of Formula (I). The invention also provides pharmaceuticalcompositionscomprising such compounds, the use of such compounds to treat diseasesassociatedwith 5-HT4 receptor activity, and processes and intermediates useful forpreparingsuch compounds. Wherein； R1 is hydrogen, halo, hydroxy, C1-4 alkyl, or C1-4alkoxy；R2 is C3-4 alkyl, or C3-6cycloakyl； R3 is hydrogen or C1-3 alkyl: R4 is -S(O)2R6or C(O)R7； R5 is hydrogen, C1-3alkyl, C2-3 alkyl substituted with -OH or C1-3alkoxy,or CH2-pyrydyl； R6 is C1-3 alkyl； or R5 and R6 taken together form C3-4alkylenyl； and R7is hydrogen, C1-3alkyl, or pyrydyl； or a pharmaceutically-acceptable salt orsolvate orstereoisomer thereof.
