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COMPOSES QUINOLEINES APPROPRIES POUR LE TRAITEMENT DE TROUBLES QUI REPONDENT A UNE MODULATION DU RECEPTEUR 5-HT<;SB>;6 <;/SB>;DE LA SEROTONINE
专利权人:
ABBOTT GMBH & CO. KG
发明人:
TURNER, SEAN COLM,HAUPT, ANDREAS,BRAJE, WILFRIED,LANGE, UDO,DRESCHER, KARLA,WICKE, KARSTEN,UNGER, LILIANE,MEZLER, MARIO,WERNET, WOLFGANG,MAYRER, MATTHIAS
申请号:
CA2681030
公开号:
CA2681030C
申请日:
2008.03.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention relates to novel quinoline compounds. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. formula (I) wherein R is a moiety of the formula (R) wherein A, R1 to R4 are as defined in the claims and the specification, n is 0, 1 or 2; m is 0, 1, 2 or 3; Ra, Rb are independently selected from the group consisting of halogen, CN, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C(O)Raa, C(O)NRccRbb and NRccRbb; X is CH2, C(O), S, S(O) or S(O)2; which is located in the 3- or 4-position of the quinoline ring; Ar is a radical Ar1, Ar2-Ar3 or Ar2-O-Ar3, wherein Ar1, Ar2 and Ar3 are each independently selected from the group consisting of aryl or hetaryl wherein aryl or hetaryl moieties may be unsubstituted or may carry 1, 2, 3 substituents Rx, wherein and physiologically tolerated acid addition salts and the N-oxides thereof.
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中国工程科技知识中心
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