The present invention relates to a combination of natural substances comprising at least one glycyrrhetinic acid and at least one guggulsterone, and to the use thereof for cosmetic applications. The present invention relates especially to vesicles (especially for topical application) comprising at least one glycyrrhetinic acid and at least one guggulsterone. The vesicles are preferably added to a cream, a lotion or a gel, the resulting cream, lotion or gel being used for the cosmetic and/or dermatological treatment of the skin and/or for the prophylaxis of the appearance of cellulite and/or ageing skin and/or for the treatment of changes in subcutaneous fatty or connective tissue, for example lipomas and other non-specific subcutaneous fat deposits, or for the regression or reduction of fat pads which are not caused by disease, such as, for example, fat pads in the face and neck region, for example lachrymal sacs, etc.本發明係關於一種包含至少一甘草次酸及至少一沒藥甾酮之天然物質之組合物及其用於化妝品應用之用途。本發明特別係關於一種囊泡(尤其是用於局部施用)包括至少一甘草次酸及至少一沒藥甾酮。該囊泡較佳係加入到乳膏劑、乳液劑或凝膠劑，所得乳膏劑、乳液劑或凝膠劑被用於皮膚的美容治療及/或皮膚治療及/或用於皮下脂肪團及/或老化皮膚外觀之預防及/或用於治療皮下脂肪或結締組織之變化，例如脂肪瘤及其他非特異性皮下脂肪堆積，或用於非經疾病引起之脂肪墊的消退或減少，例如臉部區域及頸部區域之脂肪墊，例如淚囊等。
