The invention relates to a natural substance combination containing at least one glycyrrhetinic acid and at least one guggulsterone and to the use thereof for cosmetic applications. The invention relates in particular to vesicles (in particular for topical application) that contain at least one glycyrrhetinic acid and at least one guggulsterone. Said vesicles are preferably added to a cream a lotion or a gel wherein the resulting cream the resulting lotion or the resulting gel is used for the cosmetic and/or dermatological treatment of the skin and/or for preventing the manifestation of cellulite and/or aged skin and/or for treating changes in the subcutaneous fat tissue or connective tissue such as lipomas and other unspecific subcutaneous fat deposits or for resolving or reducing non pathological fat pads such as fat pads in the face and neck region for example lachrymal sacs,etc.
