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Selective and reversible inhibitors of ubiquitin-specific protease 7
专利权人:
Hybrigenics S.A.
发明人:
COLLAND, Frédéric,GOURDEL, Marie-Edith
申请号:
ES12751080
公开号:
ES2594603T3
申请日:
2012.08.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (I '): ** Formula ** in which - R1, each identical or different, is selected from the group consisting of halogen, R, OR, NRR, CN, CF3, C (O ) R, C (O) OR, C (O) NRR ', NO2, (C1-C6) alkylene-OR, (C1-10 C6) alkylene-NRR', (C1-C6) alkylene-CO2R, (C1- C6) alkylene-CONRR ', -O- (C1-C6) alkylene-CO2R, -O- (C1-C6) alkylene-CONRR', CO2- (C1-C6) alkylene-OR, CO2- (C1- C6) alkylene-NRR ', C (O) NH- (C1-C6) alkylene-OR, CONH- (C1-C6) alkylene-NRR', OCF3, SO2R, SO3H, SO2NRR ', NHSO2R, R10C-CR11, (R10) (R11) C>; = C (R11) 2, (C1-C6) alkylene-COR, NHCOR, or (C1-C6) alkyl interrupted by at least one heteroatom chosen from O, N and S; - L1 is CH2; - q is 0, 1, 2, 3 or 4 - X 'is CR7; - R7 is OR; - n is 1 or 2; - p is 1, 2 or 3; - R3, R4, R8 and R8, each identical or different, are selected from the group consisting of H, (C1-C6) linear or branched alkyl, halogen, OH, -O- (C1-C6) alkyl, NRR ', CN, CF3, OR, C (O) R, C (O) OR or C (O) NRR'; - A is chosen from the group consisting of: - -C (O) -; - -C (O) NH-; - L2 is (C1-C6) linear or branched alkylene optionally interrupted by at least one heteroatom chosen from O, NR or S and / or optionally substituted by: R, OR, NRR ', (C1-C6) alkyl-OR, ( C1-C6) alkyl-NRR ', OC (O) R, NHC (O) R, NHC (O) NRR', CN, C (>; = NH) NHOR; - R6 is selected from the group consisting of aryl, heteroaryl, cycloalkyl, heterocycle, H, wherein the aryl, heteroaryl, cycloalkyl or heterocycle is mono or polycyclic and is optionally substituted by one or more of (C1-C6) alkyl linear or branched, halogen, NRR, CN, CF3, OR,>; = O, C (O) R, C (O) OR, NHC (O) R, OC (O) R, (C2-C6) linear alkenylene branched or C (O) NRR '; - each R and R ', identical or different, are independently selected from H, (C1-C6) linear or branched alkyl, cycloalkyl, aryl, aromatic or non-aromatic heterocycle, - (C1-C6) linear or branched alkylaryl or - ( C1-C6) linear or branched alkylheterocycle, wherein the heterocycle is aromatic or non-aromatic; optionally subs
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