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Conjugates of pyrrolo dimers [1,4] benzodiazepine as anticancer agents
专利权人:
SANOFI
发明人:
COMMERSON, ALAIN,GAUZY-LAZO, LAURENCE
申请号:
ES10761055
公开号:
ES2484690T3
申请日:
2010.08.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (I): in which: - ---- represents a single bond or a double bond with the proviso that if ---- represents a single bond then: - ---- represents a single bond ; - U and / or U ', identical or different, represents (n) independently of each other, H; - W and / or W ', identical or different, represents (n) independently of each other: OH, -OR, -OCOR, -COOR, -OCOOR, -OCONRR', a cyclic carbamate such that N10 and C11 are included in a cycle, -NRCONRR ', -OCSNHR, a cyclic thiocarbamate such that N10 and C11 are included in a cycle, -SH, -SR, -SOR, -SOOR, -SO3-, -NRSOOR', -NRR ', a cyclic amine such that N10 and C11 are included in a cycle, -NROR ', -NRCOR', -N3, -CN, Hal, a trialkylphosphonium or triarylphosphonium group; - R1, R2, R1 ', R2', identical or different, independently represent each other: H, Hal or a (C1-C6) alkyl group optionally substituted with one or more substituents chosen from: Hal, CN, NRR ' , CF3, OR, an aryl or heteroaryl group, S (O) qR with q>; = 0.1 or 2; or - R1 and R2 and / or R1 'and R2' together form respectively a double bond>; = CH2 or>; = CH-CH3; - Y and Y ', identical or different, independently represent each other H u -OR; - M represents CH or N; - ALK and ALK ', identical or different, independently represent each other an (C1-C6) alkylene group; - R and R 'represent, independently of each other, H or a (C1-C6) alkyl or aryl group optionally substituted with one or more substituents chosen from: Hal, CN, NRR', CF3, OR, an aryl group or heteroaryl; - L represents: - the group -L1-L2- in which L1 is linked to the aromatic cycle comprising M by the ALK or OALK group and represents one of the following groups:Un compuesto de fórmula (I): en la que: - ---- representa un enlace sencillo o un enlace doble con la condición de que si ---- representa un enlace sencillo entonces: - ---- representa un enlace sencillo; - U y/o U', idéntico o diferente, representa(n) independientemente el uno del otro, H; - W y/o W', idén
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