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PHOTOSENSIBILIZERS BASED ON (BACTERIO) CHLOROPHYLL FOR TREATMENT OF EYE DISEASES AND DISORDERS
专利权人:
ЙЕДА РИСЕРЧ ЭНД ДИВЕЛОПМЕНТ КО., ЛТД.
发明人:
ШЕРЦ Авигдор,САЛОМОН Йорам,МАРКОВИЧ Арие,БРЭНДИС Александр,ВАГНЕР Даниэл
申请号:
RU2014110784
公开号:
RU2014110784A
申请日:
2012.08.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The compound of chlorophyll or bacteriochlorophyll for use in photodynamic therapy (PDT) of diseases, disorders and conditions associated with an anomaly of the cornea or sclera. 2. Chlorophyll or bacteriochlorophyll according to claim 1, characterized in that said anomaly of the cornea or sclera is a thinning of the cornea and weakening of the sclera. 3. A chlorophyll or bacteriochlorophyll compound according to claim 1 or 2, which is a chlorophyll or bacteriochlorophyll derivative having the formula I, II or III: wherein M is 2H or an atom selected from the group consisting of Mg, Pd, Pt, Zn, In, Gd and Yb; X represents O or NR; R, and R each independently represents YR, or; Y represents O or S; R represents H, OH or COOR; R represents H, OH, C-C1-6 alkyl or C -Calkoxy; R is -CH = CRHal ,,, -CH, -CH = NR ,, -CH-OR, -CH-SR, -CH-Hal, -CH-R ,,, -CH-CHR, - CH-CHHal, -CH-CHOR, -CH-CHSR ,,, -COCH ,, -C (CH) = CRHal, -C (CH) -NR ,, -CH (CH) -Hal, -CH (CH ) -OR, -CH (CH) -SR ,, or -C≡CR; represents methyl or formyl; R represents O, S, NR ,, or CR-Hal; R, R, R, and each independently represents: (a) H; (b) C-Chydrocarbyl; (c) C-Chydrocarbyl substituted with one or more functional groups selected from the group consisting of halogen, nitro, oxo, OR, SR, epoxy, epithio, -CONRR ′, -COR, COOR ′ ′, -OSOR, -SOR ′ ′, -SOR, -NHSOR, -SONRR ′, -NRR ′, = N-OR, = N-NRR ′, -C (= NR) -NRR ′, -NR-NRR ′, - (R) NC (= NR) -NRR ′, O ← NR-,>; C = NR, - (CH) -NR-COR ′, - (CH) -CO-NRR ′, - O- (CH) -OR, -O- (CH) -O- (CH) -R, -PRR ′, -OPORR ′, -POHR and -OPOR′′R ′ ′, where n is an integer from 1 up to 10, a R and R ′ each independently represents H , hydrocarbyl or heterocyclyl, or R and R ′ together with the N atom to which they are attached form a 3-7 membered saturated ring, optionally containing an additional heteroatom selected from O, S and N, when1. Соединение хлорофилла или бактериохлорофилла для применения в фотодинамической терапии (ФДТ) заболеваний, расстройств и состояний, связан
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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