BERNARD MEUNIER,CÉLINE DERAEVE,MARGUERITE PITIE,CHRISTOPHE BOLDRON
申请号：
PT06794293
公开号：
PT1919894E
申请日:
2006.08.04
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
Use of polyquinoline derivatives (I) or their stereoisomers, tautomers, hydrates, solvates, salts, free forms and esters for the preparation of compositions for chelating metallic ions and/or dissolving amyloid aggregates and to treat and/or prevent disorders affecting the central nervous system e.g. neurodegenerative disorders. Use of polyquinoline derivatives of formula (I) and their stereoisomers, tautomers, hydrates, solvates, salts, free forms and esters for the preparation of compositions for chelating metallic ions and/or dissolving amyloid aggregates and to treat and/or prevent the disorders affecting the central nervous system e.g. neurodegenerative disorders. X : OR, NRR', S(O) pR, OCOR, OCOOR or a quinoline group of formula (IX)； Y 1>； : quinoline group of formula (IY), H, OR, NRR', Hal, CN, CF 3 or Alk； X' : OR, NRR', S(O) pR, OCOR or OCOOR； Z : -(A) m-(Alk) n-(A') m'-(Alk') n'-(A'') m''-(Alk'') n''； m, n, m', n', m'', n'' : 0-1； A, A '>；, A'' : -NR-, -S(O) p-, -O-, -C(=O)- or 4-11 membered cycloalkyl, heterocycle, (hetero)aryl (all optionally substituted by alkyl or T)； T : OR, NRR', CF 3, Hal, CN, S(O) pR, COOR, OCOOR, CONRR' or NRCOOR'； Alk, Alk', Alk'' : alkyl (optionally substituted by T)； R, R' : H, cycloalkyl, Alk or heteroaryl； R 1>；-R 5>；, R 1'>；-R 6'>； : H, OR, NRR', Hal, CN, CF 3, S(O) pR, COOR, OCOOR, CONRR', NRCOOR' or Alk； k : 1-2； and p : 0-2. Provided that: (1) when Y 1>； is (IY) X is OR, NRR', S(O) pR, OCOR or OCOOR； (2) when X is (IX) Y 1>； is H, OR, NRR', Hal, CN, CF 3 or Alk； (3) at least one of m, n, m', n', m'' and n'' is 1； (4) (I) excludes compounds in which X is OH, Y 1>； is (IY) (where k is 1 and X' is OH), Z is -N(butyl)- or -N(methyl)- and R 1>；-R 5>； and R 1'>；-R 6'>； are H； and (5) specifically for treatment of disorders affecting the central nervous system e.g. neurodegenerative disorders (I) excludes compounds in which X is (IX), Z is -(NH)-(CH 2) 2-(NH)-(CH 2) 2-(NH)-, Y 1>； is H and R 1>；-R
