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Benzonaphthyridineamines as autotaxin inhibitors
专利权人:
Merck Patent GmbH
发明人:
STAEHLE, Wolfgang,SCHULTZ, Melanie,SCHIEMANN, Kai
申请号:
ES11706181
公开号:
ES2562183T3
申请日:
2011.02.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compounds of formula (I) ** Formula ** in which: D represents Ar or Het, Ar represents phenyl, indanyl, naphthyl or biphenyl unsubstituted or substituted one or more times, Het represents a saturated one or two ring heterocycle, partially unsaturated or aromatic with 1, 2, 3 or 4 atoms of N, O and / or S that may be unsubstituted or substituted once or several times, X, Y each is absent independently of each other, represent -CH2-, - (CH2) 2-, -C (O) -, -CHOH- or - CH2OC (O) -, where only one of the X or Y residues may be absent, R each independently represents H, A, Cyc, (CH2) qAr or (CH2) qHet and may be substituted once or several times with R6, where in the case of A and Cyc the C chain or the C ring may also be interrupted with O, R1 each independently represents between yes R, F, Cl, Br, I, OH,>; = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3 , SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl and may be substituted once or several times with R6, R2, R3 each independently represents R, where optionally R2 and R3 together can also form Cyc or Het, which in turn can be substituted once or several times with R6, R4 represent each one independently from each other R, F, Cl, Br, I, OH,>; = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl and can be substituted once or several times with R6, R5 each independently represent each other R, F, Cl, Br, I, OH,>; = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A , phenyl and may be substituted once or several times with R6, R6 each independently represents R, F, Cl, Br, I, OH,>; = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl and, provided that from the chemical point of view a substitution is possible , they can be substituted once or several times with R, F, Cl, Br, I, OH,>;
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