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LARGE GENOMIC DNA KNOCK-IN AND USES THEREOF
专利权人:
The Jackson Laboratory
发明人:
David Bergstrom,Tiffany Leidy-Davis
申请号:
US15968943
公开号:
US20180355382A1
申请日:
2018.05.02
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention provides compositions and methods for utilizing a large capacity cloning vector (e.g., BAC) to carry a large exogenous genomic DNA (about 10-300 kb) flanked by a proximal and distal regions (10 kb) to efficiently insert into the genome of a cell in a CRISPR/Cas9-stimulated homologous recombination. Methods and compositions for microinjecting a large human gene into a mouse zygote to prepare a genetically modified mouse are also provided.
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