DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO BENZOTHIAZOLES AND 5-FLUORO BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
The invention relates to novel products of the formula (I) where: (II) is a single or double bond； F is a fluorine atom, Ra is H, HaI, alkoxy, O-cycloalkyl, —O— heterocycloalkyl； —NH-heterocycloalkyl, heteroaryl, phenyl, NHCOalk NHCOcycloalk or NR1 R2； X is S, SO or SO2, A is NH or S； W is H, alkyl, or COR with R being cycloalkyl； alkyl optionally substituted by NR3R4, alkoxy, hydroxy, phenyl, heteroaryl or heterocycloalkyl； alkoxy optionally substituted by NR3R4, i.e. a O—(CH2)n-NR3R4 radical, an O-phenyl or an O—(CH2)n-phenyl radical, with phenyl optionally substituted and n=1 to 4； or the NR1 R2 radical； R1 is H or alk and R2 is H, cycloalkyl or alkyl； R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl； R1, R2 and/or R3, R4 form a cycle together with N optionally containing O, S, N and/or NH； heterocycloalkyl, heteroaryl and phenyl and cycles all being optionally substituted； wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
