DERIVATIVES OF 6-(6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
(II) is a single or double bond F is a fluorine atom, Ra is H, HaI, alkoxy, O-cycloalkyl, -O- heterocycloalkyl -NH-cycloalkyl, -NH-heterocycloalkyl, heteroaryl, phenyl, NHCOaIk, NHCOcycloalk or NR1 R2 X is S, SO or SO2, A is NH or S W is H, alkyl, or COR with R being cycloalkyl alkyl optionally substituted by NR3R4, alkoxy, hydroxy, phenyl, heteroaryl, or heterocycloalkyl alkoxy optionally substituted by NR3R4, i.e. a O-(CH2)n-NR3R4 radical, an O-phenyl or an O-(CH2)n-phenyl radical, with phenyl optionally substituted and n = 1 to 4 or the NR1 R2 radical R1 is H or alk and R2 is H, cycloalkyl or alkyl R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl R1, R2 and/or R3,R4 form a cycle together with N optionally containing O, S, N and/or NH heterocycloalkyl, heteroaryl and phenyl and cycles all being optionally substituted wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.
