There are provided compositions and methods for prevention or treatment of Streptococcus pneumoniae (SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the C-terminal structural gene for PsaA. Methods of inducing broad spectrum mucosal immunity against SP comprising administering a vaccine comprising recombinant lipidated fusion proteins are also described.本文提供用於預防或治療肺炎鏈球菌(Streptococcus pneumoniae，SP)相關疾病的組合物及方法。更具體而言，提供包含肺炎球菌表面抗原A (PsaA)之重組型脂化融合蛋白質，該等重組型脂化融合蛋白質自N端至C端包含PsaA之N端原生脂質信號肽及PsaA之C端結構基因。亦描述誘發針對SP之廣譜黏膜免疫的方法，該方法包括投與包含重組型脂化融合蛋白質之疫苗。
