ZONHON BIOPHARMA INSTITUTE INC.;GENSUN INSTITUTE OF BIOMEDICINE CO., LTD.
发明人:
Bruce Yong Ma,Jun Wang,Dinglong Wu,Chunlin Xu,Yaofang Wang
申请号：
US15109304
公开号：
US10406235B2
申请日:
2014.07.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.
