The present application provides fusion proteins that comprise a cytokine fused to an albumin binding moiety. The fusion proteins may further comprise an antigen binding moiety such as a therapeutic antibody. The present application also provides methods of making and using the fusion proteins. The present application also provides methods of treatment comprises administering a fusion protein comprising a cytokine fused to a half-life extending domain and a second agent.本申請案提供融合蛋白，其包含融合至白蛋白結合部分之細胞激素。該等融合蛋白可進一步包含抗原結合部分，諸如治療抗體。本申請案亦提供製造及使用該等融合蛋白之方法。本申請案亦提供治療方法，其包含投與包含融合至半衰期延長域之細胞激素的融合蛋白及第二藥劑。
