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Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides
专利权人:
Peng Yu;Alexander Krantz
发明人:
Alexander Krantz,Peng Yu
申请号:
US13030772
公开号:
US08927485B2
申请日:
2011.02.18
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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