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Engineering the production of a conformational variant of occidiofungin that has enhanced inhibitory activity against fungal species
专利权人:
THE TEXAS A&M UNIVERSITY SYSTEM;MISSISSIPPI STATE UNIVERSITY
发明人:
James Leif Smith,Akshaya Ravichandran,Shien Lu,Ganyu Gu
申请号:
US14090679
公开号:
US09624270B2
申请日:
2013.11.26
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
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