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ENGINEERING THE PRODUCTION OF A CONFORMATIONAL VARIANT OF OCCIDIOFUNGIN THAT HAS ENHANCED INHIBITORY ACTIVITY AGAINST FUNGAL SPECIES
专利权人:
THE TEXAS A&M UNIVERSITY SYSTEM;MISSISSIPPI STATE UNIVERSITY
发明人:
JAMES LEIF SMITH,AKSHAYA RAVICHANDRAN,SHIEN LU,GANYU GU
申请号:
US15438934
公开号:
US20170247415A1
申请日:
2017.02.22
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar activity. This invention is directed to compositions enriched for particular occidiofungin diastereomers/conformers, methods of making compositions enriched for particular diastereomers/conformers and microorganisms suitable for producing enriched compositions of particular diastereomers/conformers. Methods of treating fungal infections or plants infected by fungi are also provided.
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