FENSOME, ANDREW,GOPALSAMY, ARIAMALA,GERSTENBERGER, BRIAN S.,EFREMOV, IVAN VIKTOROVICH,WAN, ZHAO-KUI,PIERCE, BETSY,TELLIEZ, JEAN-BAPTISTE,TRUJILLO, JOHN I.,ZHANG, LIYING,XING, LI,SAIAH, EDDINE
申请号：
CA2900855
公开号：
CA2900855A1
申请日:
2015.08.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A compound compound having the structure:(see above formula)or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where Ris hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl),CN, amino, alkylamino,dialkylamino, CF3, or hydroxyl； A is selected from the group consisting of abond, C=O, --SO2--, --(C=O)NR0--, and --(CR a R b)q-, where R0 is H or C1-C4 alkyl, and R a and R bare independently hydrogen,deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl,(C1-C6 alkyl)heteroaryl, etc.； A'is selected from the group consisting of a bond, C=O, --SO2--, --(C=O)NR0',NR0'(C=O)--, and --(CR a'R b')q--, where R0' is H or C1-C4 alkyl, and R a' and R b' areindependently hydrogen, deuterium, C1-C6alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6alkyl)heteroaryl, heteroaryl(C1-C6 alkyl),and heterocyclic(C1-C6 alkyl)； Z is --(CH2)h-- or a bond, where one or moremethylene units are optionallysubstituted by one or more C1-C3 alkyl, CN, OH, methoxy, or halo, and wheresaid alkyl may besubstituted by one or more fluorine atoms； R1 and R1' are independentlyselected from the groupconsisting of hydrogen, deuterium, C1-C4 alkyl, C3-C6 cycloalkyl, aryl,heteroaryl, aryl(C1-C6 alkyl), CN,etc., wherein said alkyl, aryl, cycloalkyl, heterocyclic, or heteroaryl isfurther optionally substituted withone or more substituents selected from the group consisting of C1¨C6 alkyl,halo, CN, C1-C4 alkylamino,C3-C6 cycloalkyl, etc.； R2 is selected from the group consisting of hydrogen,deuterium, C1-C6 alkyl, C3-C6cycloalkyl, halo, and cyano, where said alkyl may be substituted by one ormore fluorine atoms； R3 isselected from the group consisting of hydrogen, deuterium, and amino； R4 ismonocyclic or bicyclic aryl ormonocyclic or bicyclic heteroaryl wherein said aryl or heteroaryl isoptionally substituted with one or moresubstitue
