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Pyrophosphate-phosphoric acid-1 (enpp-1) transmission pipe inhibitor and its application
- 专利权人:
- INC.;MAVUPHARMA
- 发明人:
- FLORIO, VINCENT,DIETSCH, GREGORY N.,ODINGO, JOSHUA,GALLATIN, WILLIAM MICHAEL
- 申请号：
- ARP180102479
- 公开号：
- AR112537A1
- 申请日:
- 2018.08.31
- 申请国别(地区):
- AR
- 年份:
- 2019
- 代理人:
- 摘要：
- This report describes the methods and compounds to increase and improve the production of class I IFNs on site. In some embodiments, the compounds disclosed in this report are npp-1 inhibitors, pharmaceutical compounds, cancer or viral infection treatment methods. 1. Claim 1: a formula compound (1),An acceptable stereoisomer in salt, solution, or drug, characterized by X being - nr8311 -.-Is-Yes-S（=O）-S (3DO) -o-CR831223；R8313-；L is o-cr1 83040； R1 -；L1 is o-cr1 l830808 -；Y1 ES-N-O-CR1-；He's - n-o-cr2Y3 is - n-o-cr-3；1.YS8308ES-N-O-CR-830808；YS8309EES-N-O-CR-83099A-；R1，r2，R3，R830808，R83099，R8310 is hydrogen, deuterium, halogen, CN, or74955；-No.8322；-No. 7580； - No. 74966；-C (3DO) R-C (3DO) OR-C (3DO) NR Re. C833218331c833316c26, alquenilo c83322c83318326, c83311811-hydrogen-cn-or74955；-C (3DO) R-C (3DO) OR-C (3DO) NR R-S (3DO) R-S (3DO) R-S (3DO) NR Roptionally substituted C₁₋₆ alkyl, optionally substituted C₂₋₆ alkenyl, optionally substituted C₂₋₆ alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl； R⁸ and R⁹ are independently hydrogen, deuterium, halogen, -CN, -ORᵇ,-No.8322；-No. 7580； - No. 74966；optionally substituted C₁₋₆ alkyl, optionally substituted C₂₋₆ alkenyl, optionally substituted C₂₋₆ alkynyl, optionally substituted cycloalkyl, or optionally substituted heterocycloalkyl； R¹⁰ and R¹¹ are independently hydrogen, deuterium, halogen, -CN, -ORᵇ,-No.8322；-No. 7580； - No. 74966；optionally substituted C₁₋₆ alkyl, optionally substituted C₂₋₆ alkenyl, optionally substituted C₂₋₆ alkynyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl； each R¹² is independently deuterium, halogen, -CN, -ORᵇ,-No.8322；-No. 7580； - No. 74966；-C (3DO) R-C (3DO) OR-C (3DO) NR Roptionally substituted C₁₋₆ alkyl, optionally substituted C₂₋₆ alkenyl, optionally substituted C₂₋₆ alkynyl, optionally s
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
