CRESPO, Alejandro,LAN, Ping,MAL, Rudrajit,OGAWA, Anthony,SHEN, Hong,SINCLAIR, Peter J.,SUN, Zhongxiang,BUNTE, Ellen K. Vande,WU, Zhicai,LIU, Kun,DEVITA, Robert J.,SHEN, Dong-Ming,SHU, Min,TAN, John Qi
申请号：
ES12736795
公开号：
ES2618812T3
申请日:
2012.01.19
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
The compound of Formula IV: ** Formula ** or a pharmaceutically acceptable salt thereof, in which: Y is N or CRY； each RY is independently H or C1-C6 alkyl, said alkyl is optionally substituted with halo or OH； each Rx is independently H, halo, OR, or C1-C6 alkyl, said alkyl is optionally substituted with 1 to 3 substituents selected from halo, OR and C1-C6 alkyl； each R is independently H, CF3, C1-C6 alkyl or aryl, said alkyl and aryl are optionally substituted with 1 to 3 substituents selected from halo, aryl and C1-C6 alkyl； R1 is: 1) 5-membered heteroaryl or heterocyclyl, said heteroaryl or heterocyclyl are optionally substituted with one to three R5, 2) C1-C6 alkyl, said alkyl is optionally substituted with one to three substituents C1-C6 alkyl, OR, NR2 , CF3, SR, OS (O) 2R8, CN or halo, 3) - (CRa 2) nC (O) OR11, 4) (CRa 2) 0-4C (O) Rc, 5) C3-C10-R5 cycloalkyl , or 6) - (CRa 2) nOC (O) Rc； R2 is 1) C1-C6 alkyl, 2) - (CRb 2) m-C3-C6 cycloalkyl, 3) - (CRa 2) mC (O) OR11, 4) - (CRb 2) m-C2-C6 alkenyl, or 5) - (CRb 2) m-C2-C6 alkynyl, wherein said alkyl, cycloalkyl, alkenyl and alkynyl are optionally substituted with one to three groups selected from R12； R3 is phenyl, wherein said phenyl is optionally substituted with one to three R9； R4 is 1) -NR6S (O) 2R8, 2) C1-C6 alkyl, 3) halo, 4) -C (O) OR11, 5) -NH2, 6) -OR, or 7) - (CRa 2) t -SO2R10, wherein said alkyl may be optionally substituted with one to three halo, OR or C1-C6 alkyl substituents； Each R5 is independently H, OR, CN, C (O) OR11, C (O) NRR7, C1-C6 alkyl, CF3 or C3-C10 cycloalkyl, wherein said alkyl, cycloalkyl, aryl and heteroaryl may be optionally substituted with each other. three halo, OR or CF3； Each R6 is independently H, C1-C6 alkyl, C (O) OR11 or S (O) 2R8； Each R7 is independently 1) H, 2) C1-C6 alkyl, optionally substituted with 1 to 3 substituents selected from halo, OR, CN, CF3, aryl and C3-C10 cycloalkyl, wherein said aryl and cycloalkyl are optionally substituted with aryl, 3) C3-C10 cyclo
