MARLOW, ALLISON L.,WALLACE, ELI,SEO, JEONGBEOB,LYSSIKATOS, JOSEPH P.,YANG, HONG WOON,BLAKE, JIM
申请号：
ES04811727
公开号：
ES2355797T7
申请日:
2004.11.18
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A compound that includes resolved enantiomers, diastereomers and pharmaceutically acceptable salts thereof, said compound has the formula: where X is N or CR 10； R 1, R 2, R 8, R 9 and R 10 are independently hydrogen, halogen, cyano, nitro, trifluoromethyl, difluoromethyl, fluoromethyl, fluoromethoxy, difluoromethoxy, trifluoromethoxy, azido, -SR 11, -OR 3, -C (O ) R 3, -C (O) OR 3, -NR 4 C (O) OR 6, - OC (O) R 3, -NR 4 SO2R 6, -SO2NR 3 R 4, -NR 4 C (O) R 3, -C (O) NR 3 R 4, -NR 5 C (O) NR 3 R 4, -NR 5 C (NCN) NR 3 R 4, -NR 3 R 4, C1-C10 alkyl, C2 alkenyl C10, C2-C10 alkynyl, C3-C10 cycloalkyl, C3-C10 cycloalkylalkyl, -S (O) j (C1-C6 alkyl), -S (O) j (CR 4 R 5) m-aryl, aryl, arylalkyl , heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, - O (CR 4 R 5) m-aryl, -NR 4 (CR 4 R 5) m-aryl, -O (CR 4 R 5) m-heteroaryl, -NR 4 ( CR 4 R 5) m-heteroaryl, -O (CR 4 R 5) m-heterocyclyl or -NR 4 (CR 4 R 5) m-heterocyclyl, wherein any of said parts alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl are optionally substituted with one or more independently selected groups of oxo (with the proviso that it is not substituted in an aryl or heteroaryl), halogen, cyano, nitro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, azido, -NR 4 SO2R 6, -SO2NR 3 R 4, -C (O) R 3, -C (O) OR 3, -OC (O) R 3, -NR 4 C (O) OR 6, - NR 4 C (O) R 3, -C (O) NR 3 R 4, -NR 3 R 4, -NR 5 C (O) NR 3 R 4, - NR 5 C (NCN) NR 3 R 4, -OR 3, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl and heterocyclylalkyl, and wherein said aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl rings may be further substituted with one or more groups selected from halogen, hydroxy, cyano, nitro, azido, fluoromethyl, difluoromethyl, trifluoromethyl, C1-C4 alkyl, C2 alkenyl -C4, C2-C4 alkynyl, C3-C6 cycloalkyl, C3-C6 heterocycloalkyl, NR 3 R 4 and OR 3； R 7 is hydrogen, trifluoromethyl, C1-C10 alkyl, C2-C10 alkenyl, C
