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FOXM1 PEPTIDE AND MEDICINAL AGENT COMPRISING THE SAME
专利权人:
ONCOTHERAPY SCIENCE; INC.
发明人:
Yasuharu Nishimura,Kazunori Yokomine,Takuya Tsunoda,Yusuke Nakamura
申请号:
US14729752
公开号:
US20150265689A1
申请日:
2015.06.03
申请国别(地区):
US
年份:
2015
代理人:
摘要:
An objective of the present invention is to provide a means for enabling cancer immunotherapy that targets approximately 30% of various cancer patients that highly express forkhead box M1 (FOXM1) among the Japanese, by identifying FOXM1-derived peptides that can activate cancer cell-damaging human killer T cells by binding to HLA-A2. The present invention provides a peptide of (A) or (B) below:(A) a peptide including the amino acid sequence of any one of SEQ ID NOs: 1 to 3;(B) a peptide which includes the amino acid sequence of any one of SEQ ID NOs: 1 to 3,wherein one, two, or several amino acid(s) are substituted, deleted, inserted, and/or added, andwherein the peptide shows cytotoxic (killer) T cell-inducing activity.
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