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FOXM1 peptide and medicinal agent comprising the same
专利权人:
Takuya Tsunoda;Yusuke Nakamura;Yasuharu Nishimura;Kazunori Yokomine
发明人:
Yasuharu Nishimura,Kazunori Yokomine,Takuya Tsunoda,Yusuke Nakamura
申请号:
US12673432
公开号:
US08569244B2
申请日:
2008.08.12
申请国别(地区):
US
年份:
2013
代理人:
摘要:
An objective of the present invention is to provide a means for enabling cancer immunotherapy that targets approximately 30% of various cancer patients that highly express forkhead box M1 (FOXM1) among the Japanese, by identifying FOXM1-derived peptides that can activate cancer cell-damaging human killer T cells by binding to HLA-A2. The present invention provides a peptide of (A) or (B) below:(A) a peptide including the amino acid sequence of any one of SEQ ID NOs: 1 to 3;(B) a peptide which includes the amino acid sequence of any one of SEQ ID NOs: 1 to 3, wherein one, two, or several amino acid(s) are substituted, deleted, inserted, and/or added, and wherein the peptide shows cytotoxic (killer) T cell-inducing activity.
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