Shuguang Zhu;Augustus O. Okhamafe;Joyce Chou;Eric Harwood;Rampurna Gullapalli;David Ryckman;Xiao Shang
发明人:
Augustus O. Okhamafe,Joyce Chou,Rampurna Gullapalli,Eric Harwood,David Ryckman,Shuguang Zhu,Xiao Shang
申请号：
US13457867
公开号：
US20120208825A1
申请日:
2012.04.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to non-hydrate crystalline forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts.
