AUGUSTUS OKHAMAFE,JOYCE CHOU,RAMPURNA GULLAPALLI,ERIC HARWOOD,DAVID RYCKMAN,SHUGUANG ZHU,XIAO SHANG
申请号：
PH12013500773
公开号：
PH12013500773A1
申请日:
2013.04.19
申请国别(地区):
PH
年份:
2014
代理人:
摘要：
The present invention relates to non-hydrate crystalline forms of 4-amino- 5-fluoro-3 -[6-(4-methylpiperazin- 1 -yl)- 1 H-benzimidazol-2-yl] - 1 H-quinolin-2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-arnino-5-fiuoro-3-[6-(4- methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4- methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts.
