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СПОСОБЫ КОМБИНИРОВАННОЙ ТЕРАПИИ С ПРИМЕНЕНИЕМ МОЛЕКУЛ, СВЯЗЫВАЮЩИХСЯ С PSL И PCRV PSEUDOMONAS
专利权人:
МЕДИММЬЮН ЭлЭлСи (US)
发明人:
ДИДЖАНДОМЕНИКО Антонио (US),УОРРЕНЕР Пол (US),СТОУВЕР Чарльз (US),СЕЛЛМАН Брет (US),МИНТЕР Ральф (GB),ГИЛЛАРД Сандрин (GB),РАСТ Стивен (GB),ТОМИЧ Младен (US),ВЕНКАТРАМАН Вигнеш (GB),ВАРКИ Рина (US),ПЕ
申请号:
RU2014122990/10
公开号:
RU2014122990A
申请日:
2012.11.06
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An isolated binding molecule or antigen-binding fragment thereof that specifically binds to PcrV Pseudomonas, wherein the binding molecule: (a) binds to the same epitope of PcrV Pseudomonas, an antibody or antigen-binding fragment thereof, comprising a heavy chain variable region ( VH), comprising the amino acid sequence of SEQ ID NO: 216 and light chain variable region (VL), comprising the amino acid sequence of SEQ ID NO: 217 (b) carries out a competitive inhibition PcrV Pseudomonas binding to the antibody or an antigen binding f agmentom containing VH-region, comprising the amino acid sequence of SEQ ID NO: 216 and VL-region, comprising the amino acid sequence of SEQ ID NO: 217 or (c) a combination of (a) and (b) .2. . Binding molecule of claim 1 comprising: (a) CDR1 heavy chain comprising SYAMN (SEQ ID NO: 218), or a variant thereof comprising 1, 2, 3, or 4 conservative amino acid substitutions A heavy chain CDR2 comprising AITISGITAYYTDSVKG (SEQ ID NO: 219), or a variant thereof comprising 1, 2, 3, or 4 conservative amino acid substitutions and CDR3 heavy chain comprising EEFLPGTHYYYGMDV (SEQ ID NO: 220), or a variant thereof comprising 1, 2, 3, or 4 conservative amino acid substitutions (b) CDR1 light chain comprising RASQGIRNDLG (SEQ ID NO: 221) or a Alternatively, containing 1, 2, 3, or 4 conservative amino acid substitutions A light chain CDR2 comprising SASTLQS (SEQ ID NO: 222), or a variant thereof comprising 1, 2, 3, or 4 conservative amino acid substitutions and a light chain CDR3 comprising LQDYNYPWT (SEQ ID NO: 223), or a variant thereof comprising 1, 2, 3, or 4 conservative amino acid substitutions or (c) a combination of (a) and (b) .3. Binding molecule according to claim 1 comprising:. (A) heavy chain variable region that is at least 90% identical to the n1. Выделенная связывающая молекула или ее антиген-связывающий фрагмент, которая специфически связывается с PcrV Pseudomonas, где связывающая молекула:(a) связывается с тем же эпитопом PcrV Pseu
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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