PEDERSEN, Mikkel,CHRISTENSEN, Ida,LANTTO, Johan,JACOBSEN, Helle,KRAGH, Michael
申请号：
ES11797354
公开号：
ES2616961T3
申请日:
2011.10.31
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A pharmaceutical antibody composition comprising: a) a first anti-EGFR antibody molecule comprising the amino acid sequences of CDR1-3 of the heavy chain of SEQ ID NO: 73-75, respectively, and the amino acid sequences of CDR1-3 of the light chain of SEQ ID NO: 118-120, respectively and a second anti-EGFR antibody molecule comprising the amino acid sequences of CDR1-3 of the heavy chain of SEQ ID NO: 76-78 , respectively, and the amino acid sequences of CDR1-3 of the light chain of SEQ ID NO: 121-123, respectively； b) a first anti-HER2 antibody molecule comprising the amino acid sequences of CDR1-3 of the heavy chain of SEQ ID NO: 82-84, respectively, and the amino acid sequences of CDR1-3 of the light chain of SEQ ID NO: 127-129, respectively and a second anti-HER2 antibody molecule comprising the amino acid sequences of CDR1-3 of the heavy chain of SEQ ID NO: 88-90, respectively, and the amino acid sequences of CDR1-3 of the light chain of SEQ ID NO: 133-135, respectively and c) a first anti-HER antibody molecule comprising the amino acid sequences of CDR1-3 of the heavy chain of SEQ ID NO: 97 -99, respectively, and the amino acid sequences of CDR1-3 of the light chain of SEQ ID NO: 142-144, respectively, and a second anti-HER3 antibody molecule comprising the amino acid sequences of CDR1-3 of the heavy chain of SEQ ID NO: 100-102, respectively, and the sequences of CDR1-3 amino acids of the light chain of SEQ ID NO: 145-147, respectivelyUna composición farmacéutica de anticuerpo que comprende: a) una primera molécula de anticuerpo anti-EGFR que comprende las secuencias de aminoácidos de CDR1-3 de la cadena pesada de las SEQ ID NO: 73-75, respectivamente, y las secuencias de aminoácidos de CDR1-3 de la cadena ligera de las SEQ ID NO: 118-120, respectivamente y una segunda molécula de anticuerpo anti-EGFR que comprende las secuencias de aminoácidos de CDR1-3 de la cadena pesada de las SEQ ID NO: 76-78, respectivamente, y las secuencias de aminoácidos de CDR1-3 de la
