Janssen Biotech, Inc.;Janssen Biotech; Inc.;Applied Molecular Evolution Inc.
发明人:
Chen, Yan,Gardner, Debra,Knight, David M.,Lark, Michael W.,Liang, Bailin,Shealy, David J.,Song, Xiao-Yu R.,Stojanovic-Susulic, Vedrana,Sweet, Raymond W,Tam, Susan H.,Wu, Sheng-Jiun,Yang, Jing,Marquis,
申请号：
ES14184563
公开号：
ES2676732T3
申请日:
2006.04.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An isolated anti-IL-6 antibody, with completely human framework and constant regions, comprising: (i) a light chain variable region, which comprises a light chain amino acid sequence of the complementarity determining region 1 (CDRL1) of SEQ ID NO: 3, an amino acid sequence of CDRL2 of SEQ ID NO: 21, an amino acid sequence of CDRL3 of SEQ ID NO: 29, and a variable region of the heavy chain, comprising a amino acid sequence of the heavy chain of the determining region of complementarity 1 (CDRH1) of SEQ ID NO: 39, an amino acid sequence of the CDRH2 of SEQ ID NO: 59, and an amino acid sequence of the CDRH3 of SEQ ID NO: 89； or (ii) a light chain variable region, in which the CDRL1 comprises the amino acid sequence of that of SEQ ID NO: 3, the CDRL2 comprises the amino acid sequence of that of SEQ ID NO: 21, the CDRL3 comprises the amino acid sequence of SEQ ID NO: 29, and a variable region of the heavy chain in which the CDRH1 comprises the amino acid sequence of SEQ ID NO: 41, the CDRH2 comprises the amino acid sequence of SEQ ID No.: 75, and the CDRH3 comprises the amino acid sequence of SEQ ID NO: 89； or iii) a light chain variable region, in which the CDRL1 comprises the amino acid sequence of that of SEQ ID NO: 15, the CDRL2 comprises the amino acid sequence of that of SEQ ID NO: 27, the CDRL3 comprises the amino acid sequence of SEQ ID NO: 35, and a variable region of the heavy chain in which the CDRH1 comprises the amino acid sequence of SEQ ID NO: 47, the CDRH2 comprises the amino acid sequence of SEQ ID NO. : 57, and the CDRH3 comprises the amino acid sequence of SEQ ID NO: 91； or iv) a light chain variable region, in which the CDRL1 comprises the amino acid sequence of that of SEQ ID NO: 15, the CDRL2 comprises the amino acid sequence of that of SEQ ID NO: 17, the CDRL3 comprises the amino acid sequence of SEQ ID NO: 29, and a variable region of the heavy chain in which the CDRH1 comprises the amino acid sequence of SEQ ID NO: 45, the CDRH2 comprises the am
